Screening of Natural/Synthetic Compounds for Antimalarial Activity
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چکیده
Plants have been used as a traditional medicine for the treatment of malaria. Plants may provide drugs directly such as quinine from cinchona bark or they may provide template molecules on which to base further new structures by organic synthesis—artemisinin from Artemisia annua. At the NIMR, efforts are being made to do primary screening of crude extracts of plant products to screen different fractions isolated from various parts of plants and to isolate pure compounds having antimalarial properties.
منابع مشابه
Antimalarial natural products: a review
Objective: Malaria is an infectious disease commonplace in tropical countries. For many years, major antimalarial drugs consisted of natural products, but since 1930s these drugs have been largely replaced with a series of synthetic drugs. This article tries to briefly indicate that some plants which previously were used to treat malaria, as a result of deficiencies of synthetic drugs, have rev...
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Natural product-derived drugs exemplified by quinine, isolated from South American Cinchona species and artemisinin discovered in China are of immense importance for the treatment of malaria. Although malaria parasites resistant to artemisinin have not yet been found in malaria patients, the need for new antimalarial agents remains. The burden of malaria is heaviest in Africa where over a milli...
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